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New study from Prof. Haojian Zhang's laboratory reveals an important role of YBX1 in acute myeloid leukemia
?On March 24, 2021, the international renowned journal BLOOD published an article entitled "YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner", reported the molecular mechanism of YBX1 in selectively regulating the survival of myeloid leukemia cells. This work came from Dr. Haojian Zhang’s laboratory. Dr. Zhang is a profess...
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Cell research published the latest results of Dr. Bo Zhong's research team
On May 26, 2020, Prof. Bo Zhong’s group published an article entitled "USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity" on Cell Research (https://www.nature.com/articles/s41422-020-0341-6). In this study, they found a critical role of USP29 in the innate immune responses against DNA viruses and autoimmune diseases by regulating cyclic GMP-AMP sy...
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?Huang, J., Liang, Z., Guan, C., Hua, S., and Jiang, K.* (2021). WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin. J Cell Biol 220.（姜恺）AbstractWDR62 is a microcephaly-related, microtubule (MT)-associated protein (MAP) that localizes to the spindle pole and regulates spindle organization, but the underlying mechanisms remain elusive. Here, we show tha...
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?Liu, R., Zeng, L.W., Gong, R., Yuan, F., Shu, H.B., and Li, S.* (2021). mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nat Commun 12, 4227.（李姝）AbstractGlycine decarboxylase (GLDC) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. GLDC is commonly up-regulated and pl...
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Feng, M., Xie, X., Han, G., Zhang, T., Li, Y., Li, Y., Yin, R., Wang, Q., Zhang, T., Wang, P., ..., Zhang, H.* (2021). YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner. Blood.（张好建）AbstractRNA-binding proteins (RBPs) are critical regulators of transcription and translation that are often dysregulated in cancer. Although ...
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Xu, L., Zheng, Y., Li, X., Wang, A., Huo, D., Li, Q., Wang, S., Luo, Z., Liu, Y., Xu, F., Wu, X., Wu, M.*, Zhou, Y.* (2021). Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Sci Adv 7.（吴旻、周严）AbstractProper formation of area identities of the cerebral cortex is crucial for cognitive functions and social behaviors of the brain. It remains la...
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Sun, X., Liu, T., Zhao, J., Xia, H., Xie, J., Guo, Y., Zhong, L., Li, M., Yang, Q., Peng, C., Rouvet, I., Belot, A., Shu, H. B., Feng, P.*, Zhang, J.* (2020). DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity. Nat Commun 11, 6182.AbstractUpon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial defenses and certain autoimmune di...
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Zhang, M., Yang, W., Wang, P., Deng, Y., Dong, Y.T., Liu, F.F., Huang, R., Zhang, P., Duan, Y.Q., Liu, X.D., Lin, D.*, Chu, Q.*, Zhong, B.* (2020). CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nat Commun 11, 6119.AbstractThe efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the...
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