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Cell research published the latest results of Dr. Bo Zhong's research team
On May 26, 2020, Prof. Bo Zhong’s group published an article entitled "USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity" on Cell Research (https://www.nature.com/articles/s41422-020-0341-6). In this study, they found a critical role of USP29 in the innate immune responses against DNA viruses and autoimmune diseases by regulating cyclic GMP-AMP sy...
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Cell Stem Cell published the latest result of Haojian Zhang's research team
On May 12, 2020, Prof. Haojian Zhang’s group published an article entitled " Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis" on Cell Stem Cell (DOI:https://doi.org/10.1016/j.stem.2020.04.001). In this study, they link chromatin state dynamics with expression regulation of m6A modifiers and uncover a selective and critical role of ALKBH5...
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Cai, C., Geng, A., Wang, M., Yang, L., Yu, Q.C.*, and Zeng, Y.A.*(2019). Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland. Developmental biology.AbstractThe steroid hormones are instrumental for the growth of mammary epithelial cells. Our previous study indicates that hormones regulate the expression of Rspondin-1 (Rspo1). Yet, the regulatory mechanism...
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Xia, T., Yi, X.M., Wu, X., Shang, J., and Shu, H.B.*(2019). PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response. Proceedings of the National Academy of Sciences of the United States of America 116, 20063-20069.AbstractUpon cytosolic viral DNA stimulation, cGMP-AMP synthase (cGAS) catalyzes synthesis of 2'3'cGMP-AMP (...
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Zhang, J., Lee, Y.R., Dang, F., Gan, W., Menon, A.V., Katon, J.M., Hsu, C.H., Asara, J.M., Tibarewal, P., Leslie, N.R., Pandolfi, P. P. and Wei. W.*(2019). PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer discovery 9, 1306-1323.AbstractThe function of PTEN in the cytoplasm largely depends on its lipid-phosphatase activity, though which it antagonizes the PI3K-AKT onc...
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Luo, Z., Mu, L., Zheng, Y., Shen, W., Li, J., Xu, L., Zhong, B., Liu, Y.*, and Zhou, Y.*(2019c). NUMB enhances Notch signaling by repressing ubiquitination of NOTCH intracellular domain. Journal of molecular cell biology.AbstractThe release and nuclear translocation of the intracellular domain of NOTCH receptor (NICD) is the prerequisite for Notch signaling mediated transcriptional activation. ...
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